2021
Host and microbiota metabolic signals in aging and longevity
Zhou Y, Hu G, Wang MC
Nature Chemical Biologyhttps://doi.org/10.1038/s41589-021-00837-z, (2021) (Download Full Text PDF).
Chiang DY, Lahiri S, Wang G, Karch J, Wang MC, Jung SY, Heck AJR, Scholten A, Wehrens XHT
Proteomes. https://doi.org/10.3390/proteomes9020027, (2021) (Download Full Text PDF).
FoxO3 deficiency in cortical astrocytes leads to impaired lipid metabolism and aggravated amyloid pathology
Du S, Jin F, Maneix L, Gedam M, Xu Y,Catic A, Wang MC Zheng H
Aging Cell. DOI: 10.1111/acel.13432, (2021) (Download Full Text PDF).
Mitochondrial UPR through generations
Park M Wang MC
Nature Cell Biology. Aug 02 2021; https://doi.org/10.1038/s41556-021-00729-3, (2021) (Download Full Text PDF).
Cracking Genetic Codes of Longevity
Wang MC
Nature Reviews Molecular Cell Biology https://doi.org/10.1038/s41580-021-00403-4, (2021) (Download Full Text PDF).
Label-Free Imaging of Lipid Storage Dynamics in Caenorhabditis elegans using Stimulated Raman Scattering Microscopy
Mutlu AS, Chen T, Deng D, Wang MC
Journal of Visualized Experiments.May 28, 2021;(171). doi: 10.3791/61870, (2021) (Download Full Text PDF).
3D genomics across the tree of life revealscondensin II as a determinant of architecture type
Hoencamp C , Dudchenko O, Elbatsh AMO, Brahmachari S, Raaijmakers JA, Schaik TV, Cacciatore AS, Contessoto VG, Heesbeen RGHPv, ... , Mutlu AS, Wang MC, ... , Aiden EL, Rowland BD
Science. 372(6545):984-989. doi: 10.1126/science.abe2218, (2021) (Download Full Text PDF).
Dissecting lipid droplet biology with coherent Raman scattering microscopy
Chen T, Yavuz A, Wang MC
Journal of Cell Science. J Cell Sci (2022) 135 (5): jcs252353.https://doi.org/10.1242/jcs.252353, (2021) (Download Full Text PDF).
Lipid metabolism and lipid signals in aging and longevity
Mutlu AS,Duffy J,Wang MC
Developmental Cell. https://doi.org/10.1016/j.devcel.2021.03.034, (2021) (Download Full Text PDF).
2020
Enhancing intracellular accumulation and targetengagement of PROTACs with reversible covalentchemistry
Guo WH, Qi X, Yu X, Liu Y, Chung CI, Bai F, Lin X, Lu D, Wang L, Chen J, Su LH, Nomie KJ, Li F, Wang MC, Shu X, Onuchic JN, Woyach1 JA, Wang ML, Wang J
Nature Communications. DOI:2020 11:4268 | https://doi.org/10.1038/s41467-020-17997-, (2020) (Download Full Text PDF).
Hartsough LA, Park M, Kotlajich MV, Lazar JT, Han B, Lin CJ, Musteata E, Gambill L, Wang MC, Tabor JJ
eLife. DOI: https://doi.org/10.7554/eLife.56849, (2020) (Download Full Text PDF).
Molecular Mechanisms of Lysosome and Nucleus Communication
Zhao Q, Gao SM, Wang MC
Trends Biochem Sci.978-991, November 2020, (2020) (Download Full Text PDF).
Lysosomal nucleotide metabolism regulates ER proteostasis through mTOR signaling
Mak KH, Zhao Q, Hu P, Au-Yeung C, Yang J, Duraine L, Yu Y, Abu-Remaileh M, Sabatini D, Wang J, Wang MC
bioRxiv April 2020.
Optogenetic control of gut bacterial metabolism to promote longevity
Hartsough LA, Kotlajich MV, Han B, Lin CJ, Gambill L, Wang MC, Tabor JJ
bioRxiv March 2020.
Methyl-sensing nuclear receptor Liver Receptor Homolog-1 regulates mitochondrial function in mouse hepatocytes
Choi S, Dong B, Lin CJ, Heo MJ, Kim KH, Sun Z, Wagner M, Suh JM, Wang MC , Moore DD
Hepatology 71(3):1055-1069 March 2020, (2020) (Download Full Text PDF).
Escherichia coli Metabolite Profiling Leads to the Development of an RNA Interference Strain for Caenorhabditis elegans
Neve IAA, Sowa JN, Lin CJ; Sivaramakrishnan P, Herman C, Ye Y, Han L, Wang MC
G3(Bethesda) 10(1): 189-198 9 Jan 2020, (2020) (Download Full Text PDF).
Olfactory specificity regulates lipid metabolism through neuroendocrine signaling in Caenorhabditis elegans
Mutlu AS, Gao SM, Zhang H, Wang MC
Nature Communications Mar 2020, (2020) (Download Full Text PDF).
2019
Lysosomes: Signaling Hubs for Metabolic Sensing and Longevity
Savini M, Zhao Q, Wang MC
Trends in Cell Biology Aug 2019, (2019) (Download Full Text PDF).
Neve IAA, Sowa JN, Lin CJ; Sivaramakrishnan P, Herman C, Ye Y, Han L, Wang MC
bioRxiv 9 Aug 2019, (2019) (Download Full Text PDF).
Structural characterization of life- extending Caenorhabditis elegans Lipid Binding Protein 8
Tillman MC, Khadka M, Duffy J, Wang MC, Ortlund EA.
Scientific Reports 10 July 2019, (2019) (Download Full Text PDF).
The Bacterivore's Solution: Fight and Flight to Promote Survival
Lee Y, Wang MC.
Developmental Cell 49, 8 April 2019, (2019) (Download Full Text PDF).
Does Autophagy Promote Longevity? It Depends.
Savini M, Wang MC.
Cell Volume 177, Issue 2, 4 April 2019, Pages 299-314.e16. (2019) (Download Full Text PDF).
Lysosomal Signaling Promotes Longevity by Adjusting Mitochondrial Activity
Ramachandran PV, Savini M, Folick A, Hu K, Masand R, Graham BH, Wang MC.
Developmental Cell 48, 1–12. (2019) (Download Full Text PDF).
2018
‘Inside Out’– a dialogue between mitochondria and bacteria
Han B, Lin CJ, Hu G,Wang MC (2018)
The FEBS Journal DOI:10.1111/febs.14692. (2018) (Download Full Text PDF ).
Chen AJ, Li J, Jannasch A, Mutlu AS,Wang MC,Cheng JX (2018)
ChemPhysChem DOI:10.1002/cphc.201800545. (2018) (Download Full Text PDF ).
Aging: Antagonistic Pleiotropy Supported by Gut Eating
Park M, Wang MC
Current Biology 28, R871–R894(2018) (Download Full Text PDF ).
Neuronal regulation of longevity by staying cool
Lin CJ, Neve IAA, Wang MC
Genes Dev 32(3-4):197-198(2018) (Download Full Text PDF ).
Challenges and opportunities for small molecule fluorescent probes in redox biology applications
Jiang X, Wang L, Carroll SL, Chen J, Wang MC, Wang J (2018)
Antioxid Redox Signal DOI:10.1089/ars.2017.7491. [Epub ahead of print]. (2018) (Download Full Text PDF ).
2017
A Reversible Reaction-Based Fluorescent Probe for Real-Time Imaging of Glutathione Dynamics in Mitochondria
Chen J, Jiang X, Zhang C, MacKenzie KR, Stossi F, Palzkill T, Wang MC, Wang J
ACS Sens2(9): 1257–1261. doi:10.1021/acssensors.7b00425. (2017) (Download Full Text PDF ).
Wang MC
Mol Biol Cell 28(22): 2905-2907. (2017) (Download Full Text PDF ).
High-throughput screens using photo-highlighting discover BMP signaling in mitochondrial lipid oxidation
Yu Y, Mutlu AS, Liu H, Wang MC
Nat Commun 8: 865. (2017) (Download Full Text PDF ).
Quantitative real-time imaging of glutathione
Jiang X, Chen J, Bajic A, Zhang C, Song X, Carroll SL, Cai ZL, Tang M, Xue M, Cheng N, Schaaf CP, Li F, MacKenzie KR, Ferreon ACM, Xia F, Wang MC, Maletic Savatic M, Wang J
Nat Commun 8: 16087-16098. (2017) (Download Full Text PDF ).
The amyloid precursor protein is a conserved receptor for Slit to mediate axon guidance
Wang B, Li H, Mutlu SA, Bowser DA, Moore MJ, Wang MC, Zheng H
eNeuro 4(3): pii: ENEURO.0185-17. (2017) (Download Full Text PDF).
Microbial genetic composition tunes host longevity
Han B, Sivaramakrishnan P, Lin CJ, Neve IAA, Sowa JN, He J, Tay LWR, Sizovs A, Du G, Wang J, Herman C, Wang MC
Cell 169(7): 1249-1262. (2017) (Download Full Text PDF ).
Microbial Metabolites Regulate Host Lipid Metabolism through NR5A-Hedgehog signaling
Lin C, Wang MC
Nat Cell Biol 19(5): 550-557. (2017) (Download Full Text PDF).
2016
MIPEP recessive variants cause a syndrome of left ventricular non-compaction, hypotonia and infantile death
Eldomery, MK, Akdemir ZC, Vogtle F, Charng W, Mulica P, Rosenfeld JA, GambinT, Gu S, Burrage LC, Shamsi AA, Penney S, Jhangiani SN, Zimmerman HH, Muzny DM, Wang X, Tang J, Medikonda R, Ramachandran PV, Wong L, Boerwinkle E, Gibbs RA, Eng CM, Lalani SR, Hertecant J, Rodenburg RJ, Abdul-Rahman OA, Yang Y, Xia F, Wang MC, Lupski JR, Meisinger C, Sutton VR
Genome Med 8(1):106. (2016) (Download Full Text PDF ).
Chen J, Zhao M, Jiang X, Sizovs A, Wang MC, Provost CR, Huang J, Wang J
Analyst 141(4): 1209-13. (2016) (Download Full Text PDF).
Lipid Metabolism, Lipid Signaling and Longevity
Duffy J, Mutlu, AS, and Wang MC
Springer (2016) (Download Full Text PDF).
2015
Lysosomal signaling molecules regulate longevity in Caenorhabditis elegans
Folick A, Oakley HD, Yu Y, Armstrong EH, Kumari M, Sanor L, Moore DD, Ortlund EA, Zechner R, Wang MC
Science 347(6217):83-6. (2015) (Download Full Text PDF + SI).
Jessica N. Sowa, Ayse Sena Mutlu, Fan Xia, Meng C. Wang
Current Biology 25, 2284–2289. (2015) (Download Full Text PDF + SI ).
Quantitative Imaging of Glutathione in Live Cells Using a Reversible Reaction-Based Ratiometric Fluorescent Probe
Xiqian Jiang, Yong Yu, Jianwei Chen, Mingkun Zhao, Hui Chen, Xianzhou Song, Alexander J. Matzuk, Shaina L. Carroll, Xiao Tan, Antons Sizovs, Ninghui Cheng, Meng C. Wang and Jin Wang
ACS Chem Biol 10(3):864-74. (2015) (Download Full Text PDF).
Germline Stem Cells and Their Roles in the Regulation of Organism Longevity. In H. Geiger, H. Jasper and M. Florian (Eds.)
Lin CCJ, Wang MC
Stem cell aging: Mechanisms, Consequences, Rejuvenation. Springer ISBN-10: 3709112311. (2015)
Label-free biomedical imaging of lipids by stimulated Raman scattering microscopy
Ramachandran PV, Mutlu AS, Wang MC
Curr Protoc Mol Biol 109:30.3.1-30.3.17. (2015) (Download Full Text PDF).
Omega-3 and -6 fatty acids allocate somatic and germline lipids to ensure fitness during nutrient and oxidative stress in Caenorhabditis elegans
Lynn DA, Dalton HM, Sowa JN, Wang MC, Soukas AA, Curran SP
Proc Natl Acad Sci 112(50): 15378-83. (2015) (Download Full Text PDF).
Identification of lipid droplet structure-like/resident proteins in Caenorhabditis elegans
Na H, Zhang P, Chen Y, Zhu X, Liu Y, Liu Y, Xie K, Xu N, Yang F, Yu Y, Cichello S, Mak H, Wang MC, Zhang H, Liu P
Biochim Biophys Acta 1853(10 Pt A): 2481-91 (Download Full Text PDF).
2014
Gene pathways that delay Caenorhabditis elegans reproductive senescence
Wang MC, Oakley HD, Carr CE, Sowa JN, Ruvkun G
PLoS Genetics 10(12):e1004752. (2014) (Download Full Text PDF).
In vivo metabolic fingerprinting of neutral lipids with hyperspectral stimulated Raman scattering microscopy
Fu D, Yu Y, Folick A, Currie E, Farese RV Jr, Tsai TH, Xie XS, Wang MC
J Am Chem Soc 136(24):8820-8. (2014) (Download Full Text PDF).
Live-cell imaging of alkyne-tagged small biomolecules by stimulated Raman scattering
Wei L, Hu F, Shen Y, Chen Z, Yu Y, Lin CCJ, Wang MC, Min W
Nature Methods 11(4):410-2. (2014) (Download Full Text PDF + SI).
Shedding new light on lipid functions with CARS and SRS microscopy
Yu Y, Ramachandran PV, Wang MC
Biochim Biophys Acta 1841(8):1120-9. (2014) (Download Full Text PDF).
Mutations in PURA cause profound neonatal hypotonia, seizures, and encephalopathy in 5q31.3 microdeletion syndrome
Lalani SR, Zhang J, Schaaf CP, Brown CW, Magoulas P, Tsai AC, El-Gharbawy A, Wierenga KJ, Bartholomew D, Fong CT, Barbaro-Dieber T, Kukolich MK, Burrage LC, Austin E, Keller K, Pastore M, Fernandez F, Lotze T, Wilfong A, Purcarin G, Zhu W, Craigen WJ, McGuire M, Jain M, Cooney E, Azamian M, Bainbridge MN, Muzny DM, Boerwinkle E, Person RE, Niu Z, Eng CM, Lupski JR, Gibbs RA, Beaudet AL, Yang Y, Wang MC, Xia F
Am J Hum Genet 95(5):579-83. (2014) (Download Full Text PDF).
CAPER is vital for energy and redox homeostasis by integrating glucose-induced mitochondrial functions via ERR-Gabpa and stress-induced adaptive responses via NF-B-cMYCCaenorhabditis elegans
Kang YK, Putluri N, Maity S, Tsimelzon A, Ilkayeva O, Mo Q, Lonard D, Michailidis G, Sreekumar A, Newgard CB, Wang MC, Tsai SY, Tsai M, O'Malley BW
B-cMYC. PLoS Genet 11(4): e1005116. (2014) (Download Full Text PDF).
Quantitative imaging of glutathione in live cells using a reversible reaction-based ratiometric fluorescent probe inCaenorhabditis elegans
JiangX,Yu Y, Zhao M, Matzuk AJ, Chen J, Tan X, Sizovs A, Wang MC, and Wang J
ACS Chem. Biol 10(3):864-74. (2014) (Download Full Text PDF).
2013 and Before
Vibrational imaging of newly synthesized proteins in live cells by stimulated Raman scattering microscopy
Wei L, Yu Y, Shen Y, Wang MC, Min W
Proc Natl Acad Sci 110(28):11226-31. (2013) (Download Full Text PDF + SI ).
Label-free imaging of lipid dynamics using Coherent Anti-stokes Raman Scattering (CARS) and Stimulated Raman Scattering (SRS) microscopy
Folick A, Min W, Wang MC
Current Opinion in Genetics and Development 21:585-590. (2011) (Download Full Text PDF).
RNAi screening for fat regulatory genes with SRS microscopy
Wang MC, Min W, Freudiger CW, Ruvkun G, Xie XS
Nature Methods 8:135-138. (2011) (Download Full Text PDF).
RNA editing genes associated with extreme old age in humans and with lifespan inCaenorhabditis elegans
Sebastiani P, Montano M, Puca A, Solovieff N, Kojima T, Wang MC, Melista E, Meltzer M, Fischer SE, Andersen S, Hartley SH, Sedgewick A, Arai Y, Bergman A, Barzilai N, Terry DF, Riva A, Anselmi CV, Malovini A, Kitamoto A, Sawabe M, Arai T, Gondo Y, Steinberg MH, Hirose N, Atzmon G, Ruvkun G, Baldwin CT, Perls TT
PLoS One 4(12):e8210. (2009) (Download Full Text PDF ).
JNK protects Drosophila from oxidative stress by transcriptionally activating autophagy
Wu H, Wang MC, Bohmann D
Mech Dev 126, 624-637. (2009) (Download Full Text PDF).
Fat metabolism links germline stem cells and longevity in C. elegans
Wang MC, O'Rourke EJ, Ruvkun G
Science 322:957-960. (2008) (Download Full Text PDF).
JNK extends life span and limits growth by antagonizing cellular and organism-wide responses to insulin signaling
Wang MC, Bohmann D, Jasper H
Cell 121:115-125. (2005) (Download Full Text PDF).
Cyclophilin A is a proinflammatory cytokine that activates endothelial cells
Jin ZG, Lungu AO, Xie L, Wang M, Wong C, and Berk BC
Arterioscler Thromb Vasc Biol 24, 1186-91. (2004) (Download Full Text PDF).
JNK signaling confers tolerance to oxidative stress and extends lifespan in Drosophila
Wang MC, Bohmann D, Jasper H
Developmental Cell 5:811-816. (2003) (Download Full Text PDF).
